They also found non-white race, defined as African American, American Indian/Alaskan Native, Native Hawaiian, or Pacific Islander was associated with viral positivity (13.9% vs 6.9%, respectively) and hospitalization (23.9% vs 11.3%) versus white race. (A) Positive rates of neutralizing antibodies. The most frequent of them are headache, GBS, VST, and transverse myelitis. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. It is COVID infection, and the growing evidence of persistent symptoms from what has become known as "long COVID," that are the most troubling unknown out there, Goepfert says. Zietz M, Zucker J, Tatonetti NP. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. Case Rep Infect Dis. But now, there's finally some good news for a third of Americans. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. doi:10.1016/S0140-6736(21)01420-3, 15. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Participants with documented reverse transcription-polymerase chain reaction-confirmed COVID-19 or those who had been vaccinated with any other vaccine (e.g., influenza or others) or booster vaccine since the primary dose were excluded. The worst outcome of these side effects is associated with VST, why it should not be missed and treated appropriately in due time. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. -, Wang MW, Wen W, Wang N, et al. These include anaphylaxis, a severe reaction . Results: Most participants [582/595; 146 male participants, 449 female participants; mean age 35 (2650 years)] rapidly developed neutralizing antibodies after two doses of the vaccine administered 3-weeks apart. The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. In 2020, scientists started talking about a link between blood type and Covid. This result indicates that by changing the interval between vaccinations with the inactivated vaccine from the current 38 weeks to 610 weeks (12), vaccinated people can produce higher levels of neutralizing antibody. Li G, Cappuccini F, Marchevsky NG, Aley PK, Aley R, Anslow R, et al. The blood type-infection connection is not unique to the coronavirus. Interestingly, individuals with blood type A produced lower amounts of IFN- at 180240 days after vaccination and had lower neutralizing antibodies at 114 days than those with blood type B. Along with its needed effects, sars-cov-2 (covid-19) mrna-1273 vaccine (the active ingredient contained in Moderna COVID-19 Vaccine) may cause some unwanted effects. Lau YL, Fan Leung T, Sirvan Cetin B, Cagri Dinleyici E, Huang LM, Halperin SA, et al. Unfolding the determinants of COVID-19 vaccine acceptance in China. Bethesda, MD 20894, Web Policies Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, 1. Li JX, Wu SP, Guo XL, Tang R, Huang BY, Chen XQ, et al. After adjusting for age, sex, occupation, blood type, interval between doses of vaccination, vaccination duration, and BMI, the highest geometric mean concentration (GMC) of neutralizing antibodies was 53.1 IU/mL in the same-manufacturer vaccination group at 1530 days, which was slightly but significantly higher than the 44.6 IU/mL found in the mixed-manufacturer vaccination group (p < 0.001) (Table2; Figure2B). Doctors aren't yet sure if there is a link between the . Additionally, "Rh had a lower [adjusted relative risk] of severe COVID-19 illness or death.". Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion There's no need to worry about any of the flu-like symptoms. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. Furthermore, this study was the first to explore the association between the blood type of participants and humoral and cellular immune responses within 240 days after the administration of a Chinese inactivated vaccine. After the administration of the inactivated vaccine, the GMC of neutralizing antibodies decreased from 50.2 IU/mL on day 30 to 17.7 IU/mL (average decrease: 32.3%) and 13.3 IU/mL (average decrease: 25.9%) on days 180 and 240, respectively, representing an average monthly decrease of 10.1% (Figure2B). Also, if possible, get some rest. Lancet (2021) 398:12130. Post SARS-CoV-2 vaccination Guillain-Barre syndrome in 19 patients. We excluded 14 (2.4%) participants from the regression analysis and mixed model analysis due to missing data: 8 who withdrew their consent, 2 who did not answer age-related questions, 2 who missed a follow-up visit, and 2 who did not provide blood samples (Figure1). Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. doi:10.1016/j.vaccine.2022.02.065, 16. Neutralizing antibody levels usually increase after the second administration of mixed vaccines (22, 23). Among 11,000 patients, blood type A was not associated with increased viral positivity (OR 0.97, 95% CI 0.93-1.01, P=0.11), hospitalization (OR 0.89, 95% CI 0.80-0.99, P=0.03) or ICU admission (OR 0.84, 95% CI 0.69-1.02, P=0.08) compared to type O, and neither were there associations with worse outcomes among patients type B or AB, reported Jeffrey Anderson, MD, of the University of Utah School of Medicine in Salt Lake City, and colleagues. We thank all study participants, the Henan Provincial Peoples Hospital data safety monitoring board, and the study-steering committee. 2022 Nov 9;8(6):506-508. eCollection 2022 Dec 29. The concentration kinetics of IgG neutralizing antibodies were evaluated against the RBD for all study participants at least once during the 8-month timeframe and at least four times for 119 participants (20%). Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. Other neurological side effects occur in a much lower frequency. HHS Vulnerability Disclosure, Help Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). Booster shots were administered to people at least 6 months after their previous vaccination on October 20, 2021 (49). All participants were clinically evaluated and blood samples were collected for immunological evaluation on day 0. And for more on the state of the pandemic, check out These 2 Places Could Be Closing Soon, White House Official Warns. This study had limitations. Diarrhea. Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. However, some studies have people wondering if blood type affects coronavirus risk. The development of a vaccine that can overcome disadvantages including the stability of the materials used, limited immune response, and side effects, such as blood clotting, and provide a durable immune response will offer better protection from the deadly COVID-19 virus, the study said. Furthermore, based on the study of Lusting etal. What You Need to Know doi:10.1016/S2213-2600(22)00087-X, 8. That link was established pretty early on in the pandemic and scientists didn't let it go. Although not all of these side effects may occur, if they do occur they may need . This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. Reactogenicity analysis results are presented as percentage of participants. Source Reference: Anderson JL, et al "Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population" JAMA Netw Open 2021; DOI: 10.1001/jamanetworkopen.2021.7429. Nat Commun (2020) 11:5761. doi:10.1038/s41467-020-19623-x, 20. Therefore, we could not determine the level of neutralizing antibodies against viruses that cause breakthrough infection or severe infection. COVID vaccines and safety: what the research says. doi:10.3760/cma.j.cn112147-20200928-01013, 5. Unable to load your collection due to an error, Unable to load your delegates due to an error. Now, a "Covid arm" is different from a skin reaction that . Wang L, Fan JP, Xu Y, Wang JL, Wang MZ. People may start . "We don't know why that is, how long these symptoms will last or if there are effective ways to treat them. We dont know about asymptomatic carriersthat is, Type O could still pass along the virus to other people unknowingly just as much as Type A could. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. The blood group types did not affect the clinical outcomes. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: doi:10.6061/clinics/2021/e3286 Shes most passionate about hiking, traveling, mindfulness, cooking, and really, really good coffee. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. Safety of COVID-19 Vaccines Some people have no side effects. As the study is ongoing, further follow-up data on the third dose of a vaccine booster will be reported in the future. According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. Therefore, we were able to collect data of a few individuals who had received mixed vaccinations at the time. At 240 days after vaccination, the GMC of neutralizing antibodies in the mixed-manufacturer vaccination group decreased to 8.5 IU/mL, which was less than the decrease detected in the same-manufacturer vaccination group (20.5 IU/mL) (p < 0.001). The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses. The most common side effect of the vaccine is temporary soreness and swelling at the injection site. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. doi:10.1080/14760584.2021.1971523, 13. Participants with blood type A had lower levels of neutralizing antibodies than those with blood type B during 114 days after vaccination (least-square mean difference = 15.8, 95% CI 11.025.2; p = 0.044) (Table S2). In both intervention and control groups, the positive rate of neutralizing IgG antibodies specific to the SARS-CoV-2 RBD slowly increased to 84.1% from 1 to 14 days, peaked at 97.7% from 60 to 90 days, and then slowly decreased and remained at 82.9% from 180 to 240 days after the second vaccination. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. Epub 2022 Jun 1. Hearst Magazine Media, Inc. All Rights Reserved. Guillain-Barre syndrome should be monitored upon mass vaccination against SARS-CoV-2. And clotting issuesincluding strokes, kidney failure, and pulmonary embolismscome up a lot with Covid infections. Si vous ne souhaitez pas que nos partenaires et nousmmes utilisions des cookies et vos donnes personnelles pour ces motifs supplmentaires, cliquez sur Refuser tout. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. Congestion/runny nose. CNN . Blood type O seems to have the lowest risk. What Your Blood Type Has to Do With Getting Covid, This Coffee Shop Provides Free Therapy for Men, Your Privacy Choices: Opt Out of Sale/Targeted Ads. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. If You Have One of These Blood Types, You May Be Safe From COVID, It Only Takes This Long to Get COVID in a Room With Someone Who Has It, These 2 Places Could Be Closing Soon, White House Official Warns, How Likely You Are to Catch COVID in the Next Month, Expert Says, If You Have This Symptom, There's an 80 Percent Chance You Have COVID, tracked the blood types of nearly 2,200 COVID-19 patients, A blood types were significantly more likely. Blood clots with low platelets Capillary leak syndrome Guillain-Barr syndrome (GBS) Ongoing monitoring of side effects and reactions As the COVID-19 vaccine rollout continues across Canada, safety monitoring is ongoing. The studies involving human participants were reviewed and approved by the ethics committee of Henan Provincial Peoples Hospital. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). Front Public Health. You'll always want to stay at your vaccination site for at least 15 minutes after you get the shot (30 minutes if you've had a severe allergic reaction before).